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Every raw mineral and crystal that we select has been obtained using the most ethical and eco-friendly method available.
1.Are you a reseller (middle-man) or a first-hand trader?
A: First-hand trader for sure! Most of the high quality crystals are bought in raw form. Our crystal artisan will then shape the stone/crystal with sanding/polishing machine to perfection.
2.How long is the order preparation time frame after payment?
A:Pre-Order: 5-10 days after receipt of the partial payment. Ready Stock: 2-3 days after receipt of the full payment.
3.Do you offer after-sales service?
A: Definitely! Any problem with your order delivery or upon receipt of goods, please reach out to us as soon as possible. Damage shipment has to be reported within 48 hours so we can proceed to submit claim documents to the shipper.
4.Why I choose you instead of Alibaba？
A: most vendors on Alibaba try to screw you around with sweet prices but very over the top shipping.But we won’t do this，you will get free shipping on our website if you spend over $199USD. No hidden or any other extra charges and costs, At WHOLESALE-CRYSTAL.COM the price you see is the price you pay!
5. What are the payment options available?
A: We do accept Paypal or bank transfers.
6. What is the minimum order to qualify for free shipping?
A: Free shipping for orders $199USD and above (Including pre-orders)
7. How long is the delivery period? (excluding preparation time)?
A: We will mostly use DHL / FEDEX / UPS. With smooth transit, you will receive the goods in 7-12 days (subject to local custom delays).
8. Will you provide a tracking number after shipping?
A: Yes! Tracking number will be given to you via email after sending out the package. We will monitor your package to ensure smooth delivery.
9. Do you accept custom order?
A:Yes, we do, please message us to check on feasibility! We might have the necessary equipment to produce what you need.
Verla –
Hydroquinone
Overview
Hydroquinone is a potent antioxidant with multiple biological effects.
It is commonly used in various medical and cosmetic applications due to its ability
to inhibit oxidative stress and protect cellular structures.
Mechanism of Action
Hydroquinone exerts its effects primarily through antioxidant activity, where it neutralizes free radicals
and reduces oxidative damage. Its mechanisms include:
Inhibition of reactive oxygen species (ROS) production
Protection of DNA, proteins, and lipids from oxidative damage
Modulation of cellular signaling pathways
Indications and Dosage
Hydroquinone is used in the treatment of conditions involving oxidative stress, such as:
Aging-related skin conditions
Acne vulgaris
Hyperpigmentation disorders
Certain neurodegenerative conditions
The dosage of hydroquinone varies depending on the condition being treated and the specific formulation used.
Adverse Effects
While generally well-tolerated, hydroquinone can cause a range of adverse effects including:
Gastrointestinal upset
Allergic reactions
Transient increases in liver enzymes
Brown discoloration of skin and tissues (rare)
Precautions
Patients should be advised of the following precautions when using hydroquinone:
Contraindications: Use is avoided in individuals with a history of
sensitivity to it or its metabolites.
Pregnancy: Limited data on safety during pregnancy; use should be avoided unless medically
necessary and under supervision.
Drug interactions: Potential for enhanced effects when combined with
other oxidizing agents or medications that may increase
oxidative stress.
Allergic reactions: Discontinue immediately in case of allergic symptoms (e.g.,
rash, itching).
References
A comprehensive list of references supports the use and mechanisms of hydroquinone.
Further details can be found in relevant scientific studies and clinical guidelines.
# Hydroquinone: A Comprehensive Overview
## Overview
Hydroquinone (also known as para-aminophenol)
is a medication primarily used to treat hyperpigmentation disorders such as melasma
and hypomelanosis. It works by inhibiting the enzyme tyrosinase, which is responsible for the production of melanin.
## Mechanism of Action
Hydroquinone exerts its effects by competing with the
substrate tyrosine at the catalytic site of tyrosinase.
This leads to a reduction in the synthesis of melanin, thereby lightening hyperpigmented lesions.
## Indications
– **Melasma**: A common condition characterized by darkened
patches on the face, particularly in sun-exposed areas.
– **Hypomelanosis**: A rare genetic disorder causing depigmentation.
– **Post-inflammatory hypopigmentation**: Occurs after certain skin injuries or infections.
## Adverse Effects
Common side effects include:
– Dermal irritation (e.g., erythema, dryness)
– Textile dystrophy (a rare condition leading to thickened and brittle skin)
– Onycholysis (nail separation)
## Contraindications
– **Allergic reactions**: Patients with a history of allergic reactions to hydroquinone or
similar compounds should be cautious.
– **Pregnancy**: Use in pregnancy is generally avoided due to potential risks.
## Monitoring
Monitor for signs of local irritation and skin darkening.
Periodic follow-ups are recommended to assess treatment
efficacy.
## Toxicity
Hydroquinone is considered relatively safe when used as directed.
Overdosing can lead to more severe adverse effects,
including liver damage and methemoglobinemia.
## Enhancing Healthcare Team Outcomes
Effective communication between healthcare providers and patients is crucial for ensuring proper
use and monitoring of hydroquinone.
## Review Questions
1. What is the primary indication for hydroquinone?
**Answer**: Melasma and hypomelanosis.
2. How does hydroquinone inhibit melanin synthesis?
**Answer**: By competing with tyrosine at the tyrosinase catalytic site.
## References
– StatPearls NCBI Bookshelf: Hydroquinone Online.
Available from: Link to StatPearls content.
## Views
The efficacy of hydroquinone in treating hyperpigmentation is well-established, though individual responses may vary.
## In This Page
– Bulk Download: Option available for downloading relevant materials.
– Related Information: Additional resources and studies linked on the platform.
– Similar Articles in PubMed: Search for comparable studies using PubMed.
## Recent Activity
Updates and new findings related to hydroquinone usage
are regularly added to StatPearls NCBI Bookshelf.
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