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   Anabolic Steroids

   Background: Anabolic steroids are synthetic derivatives of male hormone testosterone that mimic its effects on muscle building and fat
   burning.

   Use: Commonly used by athletes, bodybuilders, and individuals seeking to enhance
   physical appearance and athletic performance. Often abused for prolonged periods,
   leading to significant health risks.

   # Anabolic Steroids: A Comprehensive Overview from StatPearls NCBI Bookshelf

   Anabolic steroids have a rich history rooted in their initial use
   as synthetic compounds designed to mimic testosterone’s muscle-building effects.
   Over time, their applications expanded beyond mere muscle growth,
   leading to clinical uses in treating conditions like muscle wasting and
   certain metabolic disorders.

   ## Account
   The development of anabolic steroids began with early experiments by scientists like Albert
   Hofmann, who synthesized andropaustrans-ene, one of the earliest anabolic compounds.
   These early iterations were later refined
   into more potent derivatives, setting the stage for their
   modern use in clinical settings. While initially intended to combat muscle wasting, anabolic steroids have since
   been repurposed and are now approved for specific therapeutic uses.

   ## Bookshelf
   StatPearls is a valuable resource available
   through the NCBI Bookshelf, offering concise yet comprehensive information on various clinical topics.
   Accessible via the NCBI website, StatPearls serves as a trusted repository of
   evidence-based medical knowledge, ideal for healthcare professionals
   seeking quick and reliable references.

   ## Anabolic Steroids
   Anabolic steroids are synthetic derivatives of testosterone that possess both anabolic (growth-promoting) and androgenic (masculinizing) properties.
   Their mechanism of action involves binding to androgen receptors, activating gene expression pathways that enhance
   muscle protein synthesis and fat metabolism.

   ## Authors & Affiliations
   Contributions come from esteemed researchers and clinicians across
   various fields, including endocrinology and pharmacology.

   Notable affiliations include institutions contributing
   to the content’s accuracy and reliability.

   ## Continuing Education Activity
   StatPearls functions as a continuing education resource, offering courses and materials that aid medical professionals
   in staying updated with clinical knowledge and practices.

   ## Indications
   Approved uses of anabolic steroids include treating muscle wasting, osteoporosis, and certain metabolic disorders.
   Despite their efficacy, off-label use is common, often for performance enhancement, despite regulatory restrictions to prevent misuse.

   ## Mechanism of Action
   Anabolic steroids affect target tissues via both genomic and
   non-genomic pathways, influencing processes like protein synthesis
   and fat redistribution, thereby promoting muscle growth and
   recovery.

   ## Administration
   Available in oral and injectable forms, dosages vary based on specific indications, with careful consideration of individual
   patient factors to optimize treatment outcomes.

   ## Adverse Effects
   Use of anabolic steroids can lead to severe adverse effects, including hepatotoxicity, cardiovascular risks, and psychiatric issues, necessitating close monitoring and patient education.

   ## Contraindications
   Conditions such as liver disease or certain cardiovascular issues contraindicate anabolic steroid use, highlighting the importance of comprehensive patient history assessment.

   ## Monitoring
   Regular monitoring includes lab tests for liver
   function and cholesterol levels to early detect adverse effects, ensuring
   patient safety and treatment efficacy.

   ## Toxicity
   Both acute overdose and chronic misuse can lead to severe health complications,
   underscoring the need for emergency care and addiction prevention strategies.

   ## Enhancing Healthcare Team Outcomes
   Effective team collaboration improves patient management, with shared
   decision-making enhancing outcomes while addressing ethical considerations related to steroid use.

   ## Review Questions
   Engage with multiple-choice questions covering mechanisms, uses, and risks to test
   comprehensive understanding of anabolic steroid applications and associated challenges.

   ## References
   Key references from StatPearls or reputable journals provide evidence-based support for the
   information presented, ensuring reliable clinical guidance.

   ## Views
   Perspectives on anabolic steroids vary, with society weighing ethical concerns
   against medical benefits. This discussion is crucial for balanced consideration of their use
   in clinical settings.

   ## Bulk Download
   Access StatPearls content via bulk download, enabling offline
   reference for convenient review and application in clinical practice.

   ## Related Information
   Explore additional resources on PubMed to expand knowledge on steroid uses beyond the provided
   context, aiding deeper understanding of clinical applications.

   ## Similar Articles in PubMed
   Find related articles to extend your knowledge base, connecting steroid use with broader medical topics for comprehensive learning.

   ## Recent Activity
   Stay updated with new research and guidelines on anabolic steroids through recent activity feeds, ensuring informed clinical practice aligned with current developments.

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